HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 431078Generated: October 26, 2026
Water → 1,4-Dimethyl-2-nitro-5-[3-(trifluoromethyl)phenoxy]benzene
https://huagongshe.com/reaction/431078
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-Chloro-2,5-dimethyl-4-nitrobenzene | HCID 252793 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1,4-Dimethyl-2-nitro-5-[3-(trifluoromethyl)phenoxy]benzene | HCID 15540071 | — |
Reaction Steps
To a suspension of sodium hydride (0.4 g of 60% in oil) in dry N-methylpyrroli-dinone (10 ml) was slowly added 3-trifluoromethylphenol (1.62 g). When effervescence had ceased, 3-chloro-6-nitro-p-xylene (1.85 g) was added and the mixture stirred at 120-40° C. for 5 hours. On cooling, the mixture was poured into water and the mixture extracted with diethyl ether (x3). The combined ether extracts were dried (MgSO4), filtered and evaporated to give the title compound as a solid, m.p. 68-71° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06656967B2 |
|---|
| Source dataset | uspto-grants-2003_12 |
|---|
| ORD ID | ord-f250edac67b04269b8718383f2b709f6 |
|---|
| Source note | uspto-grants-2003_12 |
|---|
