4-Fluorobenzaldehyde → E-4-fluorostyryl 4-chlorobenzyl sulfone

HRID 431137Notes

Reaction equation

[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][S:7]([CH2:10][C:11](O)=O)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[F:16][C:17]1[CH:24]=[CH:23][C:20](C=O)=[CH:19][CH:18]=1>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][S:7](/[CH:10]=[CH:11]/[C:20]2[CH:23]=[CH:24][C:17]([F:16])=[CH:18][CH:19]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 680234-Fluorobenzaldehyde

HCID 302767[(4-Chlorobenzyl)sulfonyl]acetic acid

Product 1

HCID 9861523E-4-fluorostyryl 4-chlorobenzyl sulfoneYield 72%

Procedure

A solution of 4-chlorobenzyl sulfonylacetic acid (0.01 mol) and 4-fluorobenzaldehyde (0.01 mol) was subjected to Procedure 1, Part B. The title compound was obtained in 72% yield.

Sources & evidence

ORD record: ord-d905bed263b94aae94760d4f1043cfaa
Source dataset: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06656973B2

Reaction notes

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