2-Aminopyridine → HCID 44517258, compound

Participants

Reaction Steps

The title compound was prepared in analogy to the procedure described in Step 14.1 but using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (Step 88.1), 2-aminopyridine, and stirring the reaction mixture for 72 h at rt. The crude product was purified by silica gel column chromatography (DCM/MeOH/NH3aq, 96:3:1), followed by trituration in Et2O, a second silica gel column chromatography (Hex/EtOAc, 1:4) and an additional trituration in Et2O. Title compound: ESI-MS: 423.1 [M+H]+; tR=4.21 min (System 1); TLC: Rf=0.19 (Hex/EtOAc, 1:4).

Provenance & Evidence