Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | MeOH tetrahydrofuran | HCID 21899815 | — |
| Reactant | 8-(2,6-Difluoro-3,5-dimethoxy-phenyl)quinoxaline-5-carboxylic acid | HCID 59292834 | — |
| Reactant | 1H-Imidazole, 2-nitro-4-(1-pyrrolidinylmethyl)- | HCID 178526898 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178493492 | HCID 178493492 | — |
Reaction Steps
The title compound was prepared in analogy to the procedures described in Example 14 but stirring the reaction mixture for 6 h at 65° C. and using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)quinoxaline-5-carboxylic acid (Step 88.1). 2-Nitro-4-pyrrolidin-1-ylmethyl-1H-imidazole (Step 19.1) instead of 2-nitroimidazole was used in Step 14.3, and Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2. The title compound: ESI-MS: 495.0 [M+H]+; tR=3.28 min (System 1); TLC: Rf=0.08 (DCM/MeOH/NH3aq, 94:5:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08536175B2 |
|---|
| Source dataset | uspto-grants-2013_09 |
|---|
| ORD ID | ord-82bfa70907c248358de3024fba870bcd |
|---|
| Source note | uspto-grants-2013_09 |
|---|
