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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 431223Generated: October 25, 2026

4-tert-Butylbenzaldehyde → Butyl-[6-(4-tert-butyl-phenyl)-2-methyl-imidazo[2,1-b]thiazol-5-yl]-amine

https://huagongshe.com/reaction/431223

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-tert-ButylbenzaldehydeHCID 70324—
ReactantButyl isocyanideHCID 76008—
Reactant2-Amino-5-methylthiazoleHCID 351770—
SolventPerchloric AcidHCID 24247—
ProductButyl-[6-(4-tert-butyl-phenyl)-2-methyl-imidazo[2,1-b]thiazol-5-yl]-amineHCID 22335555—

Reaction Steps

Compound 42 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 5-methyl-thiazol-2-yl-amine solution (0.1 M, MC), 0.575 ml (0.115 mmol) n-butylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) 4-tert-butylbenzaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) in a substance library.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06657064B2
Source datasetuspto-grants-2003_12
ORD IDord-faf91f9e6fbc4eaf99f102fa8a7ce8a2
Source noteuspto-grants-2003_12