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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 431229Generated: October 26, 2026

2-Aminothiazole → Cyclohexyl-[6-(2,4-dimethyl-phenyl)-imidazo[2,1-b]thiazol-5-yl]-amine

https://huagongshe.com/reaction/431229

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-AminothiazoleHCID 2155—
Reactant2,4-DimethylbenzaldehydeHCID 61814—
ReactantCyclohexyl isocyanideHCID 79129—
SolventPerchloric AcidHCID 24247—
ProductCyclohexyl-[6-(2,4-dimethyl-phenyl)-imidazo[2,1-b]thiazol-5-yl]-amineHCID 22335581—

Reaction Steps

Compound 50 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 2-amino thiazole solution (0.1 M, MC), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) 2,4-dimethylbenzaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) in a substance library.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06657064B2
Source datasetuspto-grants-2003_12
ORD IDord-2e0724f52e6d46bd9d1719219e1b4490
Source noteuspto-grants-2003_12