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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 431230Generated: October 25, 2026

2-Aminothiazole → Cyclohexyl-[6-(2,5-dimethylphenyl)-imidazo[2,1-b]thiazol-5-yl]-amine

https://huagongshe.com/reaction/431230

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-AminothiazoleHCID 2155—
Reactant2,5-DimethylbenzaldehydeHCID 22015—
ReactantCyclohexyl isocyanideHCID 79129—
SolventPerchloric AcidHCID 24247—
ProductCyclohexyl-[6-(2,5-dimethylphenyl)-imidazo[2,1-b]thiazol-5-yl]-amineHCID 22335571—

Reaction Steps

Compound 51 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 2-amino thiazole solution (0.1 M, MC), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) 2,5-dimethylbenzaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) in a substance library.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06657064B2
Source datasetuspto-grants-2003_12
ORD IDord-fec350a9ff16484ea6572d95db4d29ec
Source noteuspto-grants-2003_12