反应详情

温度

145 °C

1.24 g (10 mmol) of 2,4-dimethyl-6-hydroxypyrimidine in acetic anhydride (2.8 ml) were treated at RT with 1.41 g (10 mmol) of 3-chlorobenzaldehyde and the mixture was heated for 5 hours at 145° C. until completion of the reaction according to TLC analysis. The reaction mixture was cooled to RT, the crystalline solid which had formed was filtered off by suction and washed with diethyl ether to give 1.92 g (78%) of the desired (E)-2-[2-(3-chloro-phenyl)-vinyl]-6-methyl-pyrimidin-4-ol as off-white crystals. EI mass spectrum, m/e: 246.1 (M calculated for C13H11ClN2O: 246).

1. temperatureThe reaction mixture was cooled to RT
2. customthe crystalline solid which had formed
3. filtrationwas filtered off by suction
4. washwashed with diethyl ether