Phosphorus oxychloride → HCID 18763676, compound

Participants

Reaction Steps

In analogy to example 12c), by heating (E)-2-[2-(4-methoxy-phenyl)-vinyl]-6-methyl-pyrimidin-4-ol (0.3 g, 1.24 mmol) in POCl3 (2.27 ml, 24.76 mmol) at 130° C. for 4.5 h there was obtained (E)-4-chloro-2-[2-(4-methoxy-phenyl)-vinyl]-6-methyl-pyrimidine (0.306 g, 94%) as a light yellow solid. EI mass spectrum, m/e: 260.1 (M calculated for C14H13ClN2O: 260).

Provenance & Evidence