Phosphorus oxychloride → HCID 18763675, compound

Participants

Reaction Steps

In analogy to example 12c), by heating (E)-4-[2-(4-hydroxy-6-methyl-pyrimidin-2-yl)-vinyl]-benzonitrile (0.71 g, 3 mmol) in POCl3 (5.49 ml, 60 mmol) at 130° C. for 4.5 h there was obtained (E)-4-[2-(4-chloro-6-methyl-pyrimidin-2-yl)-vinyl]-benzonitrile (0.59 g, 76%) as a pink solid. EI mass spectrum, m/e: 255 (M calculated for C14H10ClN3: 255).

Provenance & Evidence