Phosphorus oxychloride → HCID 18763608, compound

Participants

Reaction Steps

In analogy to example 12c), by heating (E)-2-[2-(2,4-dichloro-phenyl)-vinyl]-6-methyl-pyrimidin-4-ol (0.5 g, 1.78 mmol) in POCl3 (3.26 ml, 35.6 mmol) at 130° C. for 4.5 h there was obtained (E)-4-chloro-2-[2-(2,4-dichloro-phenyl)-vinyl]-6-methyl-pyrimidine (0.491 g, 92%) as a pink solid. EI mass spectrum, m/e: 298 (M calculated for C13H9Cl3N2: 298).

Provenance & Evidence