Phosphorus oxychloride → HCID 18763658, compound

Participants

Reaction Steps

In analogy to example 12c), by heating (E)-2-(2-benzo[1,3]dioxol-5-yl-vinyl)-6-methyl-pyrimidin-4-ol (0.5 g, 1.95 mmol) in POCl3 (3.5 ml, 39 mmol) at 130° C. for 4.5 h there was obtained (E)-2-(2-benzo [1,3]dioxol-5-yl-vinyl)-4-chloro-6-methyl-pyrimidine (0.48 g, 90%) as a yellow solid. ISP mass spectrum, m/e: 275.2 (M+1 calculated for C14H11Cl2N2: 275).

Provenance & Evidence