Phosphorus oxychloride → HCID 18763668, compound

Participants

Reaction Steps

In analogy to example 12c),by heating (E)-2-[2-(3-methoxy-phenyl)-vinyl]-6-methyl-pyrimidin-4-ol (0.6 g, 2.48 mmol) in POCl3 (4.6 ml, 29.5 mmol) at 130° C. for 4.5 h there was obtained (E)-4-chloro-2-[2-(3-methoxy-phenyl)-vinyl]-6-methyl-pyrimidine (0.53 g, 82%) as an orange solid. ISP mass spectrum, m/e: 261.2 (M+1 calculated for C14H13ClN2O: 261).

Provenance & Evidence