HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-(2-Fluoro-3,5-dimethoxy-phenyl)quinoxaline-5-carboxylic acid → 8-(2-Fluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-(2-Fluoro-3,5-dimethoxy-phenyl)quinoxaline-5-carboxylic acid | HCID 59292866 | — |
| Reactant | 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine hydrochloride | HCID 66914536 | — |
| Product | 8-(2-Fluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide | HCID 59292919 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Step 14.1 but using 8-(2-fluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (Step 94.1), 5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine hydrochloride (Step 26.1) and stirring the reaction mixture for 6 days at rt. The crude product was purified by silica gel column chromatography (DCM/MeOH/NH3aq, 94:5:1). Title compound: ESI-MS: 531.2 [M+H]+; tR=3.40 min (System 1); TLC: Rf=0.19 (DCM/MeOH/NH3aq, 94:5:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536175B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-06e3f1cba5e94617ae85d7c8a54ed400 |
| Source note | uspto-grants-2013_09 |