Phosphorus oxychloride → HCID 18763594, compound

Participants

Reaction Steps

In analogy to example 12c), by heating (E)-6-methyl-2-[2-(4-methylsulfanyl-phenyl)-vinyl]-pyrimidin-4-ol (2 g, 7.74 mmol) in POCl3 (14 ml, 0.15 mol) at 130° C. for 4.5 h there was obtained (E)-4-chloro-6-methyl-2-[2-(4-methylsulfanyl-phenyl)-vinyl]-pyrimidine (1.99 g, 93%) as an off-white solid. EI mass spectrum, m/e: 276.1 (M calculated for C14H13ClN2S: 276).

Provenance & Evidence