Phosphorus oxychloride → HCID 18763600, compound

Participants

Reaction Steps

In analogy to example 12c), by heating (E)-2-[2-(3-chloro-4-fluorofluoro-phenyl)-vinyl]-6-methyl-pyrimidin-4-ol (1.85 g, 7 mmol) in POCl3 (12.83 ml, 0.14 mol) at 130° C. for 4.5 h there was obtained (E)-4-chloro-2-[2-(3-chloro-4-fluoro-phenyl)-vinyl]-6-methyl-pyrimidine (1.65 g, 83%) as a yellow solid. EI mass spectrum, m/e: 282 (M+1 calculated for C13H9Cl2FN2: 282).

Provenance & Evidence