Phosphorus oxychloride → HCID 18763623, compound

Participants

Reaction Steps

In analogy to example 12c), by heating was (E)-2-[2-(3-nitro-phenyl)-vinyl]-6-methyl-pyrimidin-4-ol (1.28 g, 5 mmol) in POCl3 (9.16 ml, 0.1 mol) at 130° C. for 4.5 h there was obtained (E)-4-chloro-2-[2-(3-nitro-phenyl)-vinyl]-6-methyl-pyrimidine (0.97 g, 71%) as an off-white solid. EI mass spectrum, m/e: 275 (M calculated for C13H10ClN3O2: 275).

Provenance & Evidence