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2-Methylbutanal → (S)-3-ethyl-2-{[(S)-1-phenylethyl]amino}pentanenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methylbutanal | HCID 7284 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | Benzenemethanamine, alpha-methyl-, hydrochloride (1:1), (alphaS)- | HCID 12236039 | — |
| 反応物 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | (S)-3-ethyl-2-{[(S)-1-phenylethyl]amino}pentanenitrile | HCID 11644310 | 74% |
反応手順
To (S)-(−)-α-methylbenzylamine hydrochloride salt (1.2 g, 7.6 mmol) in 80 mL of 1:1 MeOH/H2O was added potassium cyanide (0.5 g, 7.6 mmol) and 2-methylbutyraldehyde (0.94 mL, 7.6 mmol). A precipitate formed after 30 min. After 20 h, the suspension was filtered and washed with H2O to give (S)-3-ethyl-2-{[(S)-1-phenylethyl]amino}pentanenitrile as a white powder (1.29 g, 74%). Mass Spectrum (+ESI): 310 (M+H)+. Anal. Calc'd for C15H22N2: C, 78.21; H, 9.63; N, 12.16. Found: C, 77.90; H, 9.75; N, 12.32.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06657070B2 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-44ca88bdd66b4663afdcd16836ac4ff0 |
| 出典メモ | uspto-grants-2003_12 |