HRID431312

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)[C@H](Cc1ccccc1)NS(=O)(=O)c1cccs1

HCID704092

N-(2-Thienylsulfonyl)-L-phenylalanine

C13H13NO4S2

结构：CC(C)CN([C@@H](CCCCNC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)S(=O)(=O)c1ccc([N+](=O)[O-])cc1

HCID3013754

未命名化合物

PRODUCTS

生成物

结构：CC(C)CN([C@@H](CCCCNC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)c1cccs1)C(=O)O)S(=O)(=O)c1ccc([N+](=O)[O-])cc1

HCID508552

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from solid phase bound Nα-isobutyl-Nα-(4-nitrobenzenesulfonyl)-Nε-(9-fluorenylmethoxycarbonyl)-L-lysine as described in general procedure Bb using Nα-(2-thiophenesulfonyl)-L-phenylalanine (300 mg, 1.2 mmol) which was prepared in step A of example 24. The final product was purified by preparative HPLC to yield 46 mg (54%) of the desired material.

WORKUP

后处理

customwas prepared in step A of example 24
customThe final product was purified by preparative HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8137b00af99f4e49872c428f2db8497b
来源数据集: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06656965B2
来源说明: uspto-grants-2003_12

反应 SMILES

[CH2:1]([N:5]([S:32]([C:35]1[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][CH:36]=1)(=[O:34])=[O:33])[C@H:6]([C:29]([OH:31])=[O:30])[CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](OCC1C2C=CC=CC=2C2C1=CC=CC=2)=[O:13])[CH:2]([CH3:4])[CH3:3].[S:44]1[CH:48]=[CH:47][CH:46]=[C:45]1[S:49]([NH:52][C@H:53](C(O)=O)[CH2:54][C:55]1[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=1)(=[O:51])=[O:50]>>[CH3:4][CH:2]([CH2:1][N:5]([S:32]([C:35]1[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][CH:36]=1)(=[O:33])=[O:34])[C@H:6]([C:29]([OH:31])=[O:30])[CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([C@@H:53]([NH:52][S:49]([C:45]1[S:44][CH:48]=[CH:47][CH:46]=1)(=[O:51])=[O:50])[CH2:54][C:55]1[CH:56]=[CH:57][CH:58]=[CH:59][CH:60]=1)=[O:13])[CH3:3]