HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-tert-Butoxycarbonyl-L-tryptophan → (2S)-6-[[(2S)-2-(tert-butoxycarbonylamino)-3-(3H-indol-3-yl)propanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-tert-Butoxycarbonyl-L-tryptophan | HCID 83169 | — |
| Reactant | Nalpha-isobutyl-Nalpha-(4-methylbenzenesulfonyl)-L-lysine | HCID 23552860 | — |
| Product | (2S)-6-[[(2S)-2-(tert-butoxycarbonylamino)-3-(3H-indol-3-yl)propanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid | HCID 508607 | — |
Reaction Steps
The title compound was prepared from Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-L-lysine (100 mg, 0.29 mmol, example 1, step E) as described in general procedure Bc using commercially available Nα-tert-butoxycarbonyl-L-tryptophan (90 mg, 0.3 mmol). The final product was triturated with ether to yield 157 mg (81%) of the desired material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06656965B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-13178a7829a2436fb5f3061916aa81d6 |
| Source note | uspto-grants-2003_12 |