反应详情

温度

35 °C

To a nitrogen purged 5 liter 4-neck flask fitted with a condenser, mechanical stirrer, addition funnel, and temperature probe, was added 325 mesh iron dust, which can be obtained from Aldrich, Milwaukee, Wis. (220 g, 3.9 mol, 8 equiv), water (800 mL), and glacial acetic acid (5 mL). Over the next hour, some frothing occurred and the temperature rose to 28° C. In a separate container, 2,4-dinitrobenzaldehyde (97 g, 0.49 mol, 1 equiv) was dissolved in 1:1 glacial acetic acid/ethyl acetate (800 mL). 2,4-Dinitrobenzaldehyde can be purchased from Aldrich, Milwaukee, Wis. About 5 mL of the 2,4-dinitrobenzaldehyde solution was added dropwise to the iron mixture, which led to a dissipation of the frothing. The reaction mixture was warmed to 35° C. with a steam bath. Without further heating, the remaining dinitrobenzaldehyde solution was added at such a rate as to maintain the temperature below 50° C. The addition was completed after 6 hours. The reaction mixture was diluted with water (1 L) and diatomaceous earth (BNL Fine Chemicals and Reagents, Meriden, Conn.) was added (100 g). The reaction mixture was stirred an additional 3 hours at which point the temperature had dropped to 25° C. The solids were removed by filtration. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (3×400 mL). The extracts were then used to wash the solids from the initial filtration. The organic layers were combined and washed with water (400 mL) and saturated aqueous NaHCO3 (3×400 mL). The combined organic layers were dried over MgSO4 and Darco G-60® (activated charcoal; BNL Fine Chemicals and Reagents, Meriden, Conn.) (10 g). After filtration to remove the drying agents, the organic layers were concentrated in vacuo to a slurry and diluted with 1 L of hexanes. The precipitated solids were collected by suction filtration and dried in air to give 2,4-diaminobenzaldehyde (48 g, 71%) as a light yellow solid.

1. customTo a nitrogen purged 5 liter 4-neck flask
2. customfitted with a condenser, mechanical stirrer, addition funnel
3. additiontemperature probe, was added 325 mesh iron dust, which
4. customrose to 28° C
5. temperatureto maintain the temperature below 50° C
6. additionThe addition
7. additionwas added (100 g)
8. additionhad dropped to 25° C
9. customThe solids were removed by filtration
10. customThe organic layer was separated
11. extractionthe aqueous layer was extracted with ethyl acetate (3×400 mL)
12. washto wash the solids from the initial
13. filtrationfiltration
14. washwashed with water (400 mL) and saturated aqueous NaHCO3 (3×400 mL)
15. dry with materialThe combined organic layers were dried over MgSO4 and Darco G-60® (activated charcoal; BNL Fine Chemicals and Reagents, Meriden, Conn.) (10 g)
16. filtrationAfter filtration
17. customto remove the drying agents
18. concentrationthe organic layers were concentrated in vacuo to a slurry
19. additiondiluted with 1 L of hexanes
20. filtrationThe precipitated solids were collected by suction filtration
21. customdried in air