HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 20607510, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Tri-o-tolylphosphine | HCID 80271 | — |
| Reactant | 1,3-Benzenedicarboxylic acid, 5-bromo-, 1,3-dimethyl ester | HCID 103954 | — |
| Reactant | (Naphthalen-2-yl)boronic acid | HCID 2734375 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 20607510 | HCID 20607510 | 75% |
Reaction Steps
A solution of 5-bromoisophthalic acid dimethylester (544 mg, 2 mmol), 2-naphthaleneboronic acid (342 mg, 2 mmol), Pd(OAc)2 (8 mg), tri-o-tolylphosphine (30 mg) and 5 ml Et3N (5 ml) in 10 ml DMF was stirred at 100° C. for overnight The reaction mixture was purified by silica gel column eluted by 20% EtAc in hexane to afford the product (75% yield). 1H NMR (Acetone-d6, 400 MHz), 8.55 (s, 1H), 8.45 (s, 2H), 8.17 (d, 1H), 7.91 (d, 1H), 7.88 (d, 1H), 7.77 (t, 1H), 7.67 (t, 1H), 7.38 (m, 2H), 4.03 (s, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06656971B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-7c110c8093c34a54b0ca665de0b16b1f |
| Source note | uspto-grants-2003_12 |