Potassium Hydroxide → HCID 18763426, compound

HRID 431376Notes

Reaction equation

HRID 431376 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:24]=[CH:25][CH:26]=1)[CH2:8][O:9][C:10]1[CH:11]=[C:12]([C:20]([O:22]C)=[O:21])[CH:13]=[C:14]([CH:19]=1)[C:15]([O:17]C)=[O:16])=[O:4].[OH-].[K+]>CCO>[C:3]([C:5]1[CH:6]=[C:7]([CH:24]=[CH:25][CH:26]=1)[CH2:8][O:9][C:10]1[CH:11]=[C:12]([C:20]([OH:22])=[O:21])[CH:13]=[C:14]([CH:19]=1)[C:15]([OH:17])=[O:16])([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 18763405HCID 18763405, compound

Product 1

HCID 18763426HCID 18763426, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of dimethyl 5-[3-(methoxycarbonyl)benzyloxy]isophthalate (6.36 g, 16.5 mmol) in the mixture of KOH (15% aq., 45 mL) and EtOH (100 mL) was refluxed for 0.5 h, then cooled to room temperature and stirred overnight. The formed solution was extracted with dichloromethane (50 mL). The aqueous layer was separated, acidified with HCl conc. (to pH 2), and bulky precipitate formed was filtered and air-dried. White microcrystals; yield 4.71 g (97%).

Workup

  1. temperaturewas refluxed for 0.5 h
  2. extractionThe formed solution was extracted with dichloromethane (50 mL)
  3. customThe aqueous layer was separated
  4. customformed
  5. filtrationwas filtered
  6. customair-dried

Sources & evidence

ORD record
ord-4a47c1d92d624a86889dfc04e54c7a32
Source dataset
uspto-grants-2003_12
Patent number
US06656971B2

Reaction notes

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