3-(Trifluoromethyl)aniline → 3,5-Di(benzyloxy)-3'-(trifluoromethyl)benzanilid

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Reaction Steps

(Examplary Compound 8). The title compound was prepared according to the procedure of Scheme I-A, starting from 3,5-bis(benzyloxy)benzoic acid chloride and 3-(trifluoromethyl)aniline in THF solution. White solid, yield 0.250 g (69%). 1H NMR (DMSO-d6, 400 MHz), δ: 10.47 (s, 1H); 8.24 (s, 1H); 8.06 (d, J=8.3 Hz, 1H); 7.60 (t, J=8.0 Hz, 1H); 7.51-7.32 (m, 11H); 7.25 (s, 2H); 6.95 (s, 1H); 5.18 (s, 4H). Anal: Calcd. for C28H22F3NO3: 70.43; H, 4.64; N, 2.93. Found: C, 70.58; H, 4.67; N, 2.91.

Provenance & Evidence