2-Chloroethanol → HCID 18760949, compound

Participants

Reaction Steps

0.5 g of N-(2,5-dimethyl-4-nitro-2H-pyrazol-3-yl)-N′,N′-dimethylpropane-1,3-diamine and 2.2 g of 2-chloroethanol were introduced into a 10 ml three-necked round-bottomed flask equipped with a magnetic stirrer, a thermometer and a condenser. The reaction medium was maintained at reflux for 2 hours. The medium was cooled to room temperature and diluted with 50 ml of ethyl acetate. The precipitate was filtered off. 0.55 g of [3-(2,5-dimethyl-4-nitro-2H-pyrazol-3-yl-amino)propyl](2-hydroxyethyl)dimethylammonium chloride was obtained in the form of yellow crystals, in a yield of 82%.

Provenance & Evidence