HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(2-Methoxycarbonyl-vinyl)-thiophene-2-carboxylic acid → 5-(2-Methoxycarbonyl-ethyl)-thiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(2-Methoxycarbonyl-vinyl)-thiophene-2-carboxylic acid | HCID 54208961 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(2-Methoxycarbonyl-ethyl)-thiophene-2-carboxylic acid | HCID 10867633 | — |
Reaction Steps
2.37 g (11.18 mmol) of 5-(2-methoxycarbonyl-vinyl)-thiophene-2-carboxylic acid were dissolved in 170 ml of methanol. After addition of 500 mg of 10% palladium on charcoal (Degussa E 101 R/D 10%) the mixture was hydrogenated for 7 hours at atmospheric pressure (approx. 1 bar) and room temperature. After filtration and evaporation the yield of the title compound was 2.4 g (purity>99% (HPLC)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06660728B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-a687f507f94645a0a8515b24d9c7d895 |
| Source note | uspto-grants-2003_12 |