反应详情

7.5 g of ethyl 2-oxocyclohexane-4-carboxylate and 9.6 g of 4-chlorobenzamidine hydrochloride were introduced into 50 ml of methanol. 5.6 g of potassium tert-butylate were added with stirring. The reaction mixture was stirred under reflux for 4 hours and then poured onto ice water. The crystalline product was filtered off with suction, washed with water and recrystallized from dimethylformamide. Yield: 8.8 g; m.p.: >300° C.

1. stirringThe reaction mixture was stirred
2. temperatureunder reflux for 4 hours
3. additionpoured onto ice water
4. filtrationThe crystalline product was filtered off with suction
5. washwashed with water
6. customrecrystallized from dimethylformamide