Phosphorus oxychloride → 2-(4-Chlorophenyl)4-chloro-5,6,7,8-tetrahydroquinazoline

Participants

Reaction Steps

8.0 g of 2-(4-chlorophenyl)4-hydroxy-5,6,7,8-tetrahydroquinazoline were heated to 100° C. in 10 ml of phosphorus oxychloride. After 3 hours, the cooled solution was carefully poured onto ice water. The crystalline product was filtered off with suction, washed well with water and dried in vacuo at room temperature. Yield: 6.2 g; m.p.: 121° C.

Provenance & Evidence