2-(Methylamino)ethanol → HCID 11485905, compound

Participants

Reaction Steps

To a solution of 2-methylaminoethanol (1.0 g, 13 mmol) and diisopropylethylamine (5.8 ml, 33 mmol) in dichloromethane (50 ml) at room temperature was added 3-methylphenylsulfonyl chloride (5.6 g, 29 mmol). The solution was heated to reflux under argon for 12 hours then cooled and partitioned between saturated aqueous sodium bicarbonate and dichloromethane. The organic phase was dried over sodium sulfate and concentrated in vacuo. The residue was purified by silica gel chromatography to afford the title compound (2.5 g, 50%).

Provenance & Evidence