反应详情

温度

190 °C

A mixture of 4-piperidine carboxylic acid (5.30 g, 40 mmol), 1,2-diaminobenzene (4.32 g, 40 mmol) and polyphosphoric acid (40 g) were heated to 190° C. for 14 hours. Cooled, diluted with water (150 ml) and basified with 50% KOH to pH 8. Solution cooled in an ice/salt bath to give a precipitate which was collected by filtration and washed with water. Solid dried in vacuo to afford the title compound (8.0 g, 100%).

1. temperatureCooled
2. temperatureSolution cooled in an ice/salt bath
3. customto give a precipitate which
4. filtrationwas collected by filtration
5. washwashed with water
6. customSolid dried in vacuo