反应详情

温度

68 °C

Methyl 3-[2-benzyloxy-5-(2-chloroethyl)-4-nitroanilino]4,4,4-trifluoro-2-butenoate (0.035 g, 0.0763 mmol) was dried under high vacuum in a round bottom flask. Palladium II acetate (0.034 g, 0.153 mmol) was added, the flask was then covered with a septum and flushed with N2. Dry dimethyl acetamiide (20 mL) was then added via syringe under N2. The solution was then degassed three times under vacuum for thirty minutes and purged with N2. The solution was then stirred for six hours and fifteen minutes in an oil bath at 68° C. The solution was then diluted with CHCl3 (100 mL) and washed with water three times (100 mL). The organic layer was dried with sodium sulfate, gravity filtered and concentrated on rotovap. The dimethylacetamide was removed under high vacuum Kugelrohr distillation (50° C., 0.25 mm Hg). The residue was purified on silica gel column using methylene chloride as a solvent to yield methyl 7-benzyloxy-4-(2-cloroethyl)-5-nitro-2-trifluoromethylindole-3-carboxylate as a yellow solid. Total yield: 0.010 g (0.022 mmol, 29%). TLC (methylene chloride) Rf320.75.500 MHz 1H-NMR (CDCl3) 9.24 (s br, 1H), 7.46 (m, 5H), 7.44 (s, 1H), 5.26 (s, 2H), 4.01 (s, 3H), 3.82 (t, 7.5, 2H), 3.63 (t, 7.5, 2H). IR (neat) 3036, 2952, 2915, 2850, 1732, 1713, 1695, 1576, 1534, 1503, 1451, 1337, 1259, 865, 802. EI-MS (relative intensity) 456 (M+, 3), 420 (M+−HCl, 3). Accurate mass for C20H16O9N235ClF3: calcd. 456.0700, obsd. 456.0695.

1. customflushed with N2
2. additionDry dimethyl acetamiide (20 mL) was then added via syringe under N2
3. customThe solution was then degassed three times under vacuum for thirty minutes
4. custompurged with N2
5. additionThe solution was then diluted with CHCl3 (100 mL)
6. washwashed with water three times (100 mL)
7. dry with materialThe organic layer was dried with sodium sulfate, gravity
8. filtrationfiltered
9. concentrationconcentrated on rotovap
10. customThe dimethylacetamide was removed under high vacuum Kugelrohr distillation (50° C., 0.25 mm Hg)
11. customThe residue was purified on silica gel column