Hydrochloric Acid → HCID 86759296, compound

Participants

Reaction Steps

To a solution of Ethyl 3-{[(2R, 4S)-2-(4,5-diphenyloxazol-2-yl)-4-methoxypyrrolidin-1-yl]methyl}phenoxyacetate (3.00 g) in EtOH (30 mL) was added 1N NaOH solution (6.00 mL) at 5° C., and the mixture was stirred at room temperature for 1 hour. To the reaction mixture was added 1N HCl (6.00 mL) at 5° C. and evaporated. The residue was extracted with EtOAc, washed with water and brine, dried (Na2SO4), and evaporated in vacuo to give 3-{[(2R, 4S)-2-(4,5-diphenyloxazol-2-yl)-4-methoxypyrrolidin-1-yl]methyl}phenoxyacetic acid (2.75 g).

Provenance & Evidence