Hexane → HCID 86759298, compound

Participants

Reaction Steps

To a solution of 3-{[(2R, 4S)-2-(4,5-diphenyloxazol-2-yl)-4-methoxypyrrolidin-1-yl]methyl}phenoxyacetic acid (100 mg) in EtOH (0.65 mL) was added a solution of L-(+)-tartaric acid (32 mg) in EtOH (1.3 mL) at room temperature. To the mixture was added n-hexane (3.9 mL), and the mixture was stirred at room temperature for 2 hours. The resulting precipitate was collected and dried under reduced pressure to give 3-{[(2R, 4S)-2-(4,5-diphenyloxazol-2-yl)-4-methoxypyrrolidin-1-yl]methyl}phenoxyacetic acid tartrate (a L-(+)-tartaric acid addition salt of 3-{[(2R, 4S)-2-(4,5-diphenyloxazol-2-yl)-4-methoxypyrrolidin 1-yl]methyl}phenoxyacetic acid) (102 mg).

Provenance & Evidence