反应详情

Into a 3-necked round bottom flask under a blanket of nitrogen was placed 5% palladium catalyst on charcoal (771 mg). A solution of 2-(2-methyl-1-buten-4-yl) indole (671 mg) in ethanol (36 ml) was added to the flask, which was evacuated and charged with hydrogen twice. The mixture was stirred vigorously under hydrogen (1 atmosphere) for 2 hours, followed by filtration through a pad of Celite. The solvent was removed under reduced pressure and the crude residue was purified by flash chromatography (3% ethyl acetate/hexane) to give 2-(3-methyl-n-butyl)indole (400 mg, 59%) as a yellow crystalline solid.

1. customInto a 3-necked round bottom flask under a blanket of nitrogen was placed
2. customwas evacuated
3. additioncharged with hydrogen twice
4. filtrationfollowed by filtration through a pad of Celite
5. customThe solvent was removed under reduced pressure
6. customthe crude residue was purified by flash chromatography (3% ethyl acetate/hexane)