HCID 70033002, compound → HCID 70009631, compound

HRID 431825Notes

Reaction equation

HRID 431825 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[C:9]([CH3:11])[N:8]=[C:7]([N:12]2[CH2:16][C@H:15]([S:17][C:18]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:14][C@H:13]2[CH2:37][O:38][CH2:39][C:40]2[CH:45]=[C:44]([F:46])[C:43]([F:47])=[CH:42][C:41]=2[F:48])[N:6]=1)=[O:4]>O1CCOCC1>[CH3:11][C:9]1[N:8]=[C:7]([N:12]2[CH2:16][C@H:15]([S:17][C:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH2:14][C@H:13]2[CH2:37][O:38][CH2:39][C:40]2[CH:45]=[C:44]([F:46])[C:43]([F:47])=[CH:42][C:41]=2[F:48])[N:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:10]=1

Participants

3

Reactant 1

HCID 70033002HCID 70033002, compound

Product 1

HCID 70009631HCID 70009631, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(2S,4R)-6-Methyl-2-[2-(2,4,5-trifluoro-benzyloxymethyl)-4-tritylsulfanyl-pyrrolidin-1-yl]-pyrimidine-4-carboxylic acid methyl ester was hydrolyzed following the general method for hydrolysis of an ester (ETOH/dioxane) to give (2S,4R)-6-Methyl-2-[2-(2,4,5-trifluoro-benzyloxymethyl)-4-tritylsulfanyl-pyrrolidin-1-yl]-pyrimidine-4-carboxylic acid, MS: 656 (MH+).

Sources & evidence

ORD record
ord-88219916b7ef4f8fb8b22e8a79a55ca8
Source dataset
uspto-grants-2003_12
Patent number
US06660738B2

Reaction notes

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