HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43184Generated: October 26, 2026
Sodium Bicarbonate → HCID 59292839, compound
https://huagongshe.com/reaction/43184
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Trimethylaluminum | HCID 16682925 | — |
| Reactant | HCID 62183450 | HCID 62183450 | — |
| Reactant | 8-(2-Chloro-6-fluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester | HCID 86641146 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 59292839 | HCID 59292839 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Example 115 but using 8-(2-chloro-6-fluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 144.1), 2-[(6-amino-pyridin-3-ylmethyl)-methyl-amino]-acetamide (Step 118.1), 2 equiv of trimethyl aluminum, stirring the reaction mixture for 6 h at 80° C. and pouring it onto a saturated aqueous solution of NaHCO3 and DCM. The title compound: ESI-MS: 539.0 [M+H]+; tR=3.61 min (System 1); TLC: Rf=0.49 (DCM/MeOH/NH3aq, 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08536175B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-1d515b8624424224a9a2f3d6c19bb3f1 |
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| Source note | uspto-grants-2013_09 |
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