HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopyridine → 2-(3-Vinylphenyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopyridine | HCID 7973 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Vinylphenylboronic Acid (contains varying amounts of Anhydride) | HCID 4366886 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(3-Vinylphenyl)pyridine | HCID 18761706 | 80% |
Reaction Steps
The reaction was performed with 3-vinyl-phenylboronic acid (10 g, 0.0676 mol), 2-bromopyridine (12.64 g, 0.08 mol), tetrahydrofuran (100 ml), 2M potassium carbonate aqueous solution (26 ml), and tetrakis(triphenylphosphine) palladium (Pd(Ph3)4, 0.06 g, 1 mol %) according to Example 1. The yield was 80%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06660821B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-87337c92711549049cd4b74d0c50d7b8 |
| Source note | uspto-grants-2003_12 |