Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Fluoride → 2-Cyano-3-fluoropyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Fluoride | HCID 522689 | — |
| 반응물 | 3-Chloropyridine-2-carbonitrile | HCID 818258 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 2-Cyano-3-fluoropyridine | HCID 7060408 | 50.1% |
반응 단계
A solution of 2-cyano-3-chloropyridine (1 g, 7.22 mmol) in 1-methyl-2-pyrrolidinone (25 mL) was treated with potassium fluoride (1.26 g, 21.68 mmol) and heated at reflux for 18 hours. After cooling, the reaction was diluted with ethyl acetate and extracted with water and brine. Silica gel chromatography afforded 442 mg (50%) of 2-cyano-3-fluoropyridine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06660753B2 |
| 출처 데이터셋 | uspto-grants-2003_12 |
| ORD ID | ord-014da495d5b5402d8cbd5806a0c66b61 |
| 출처 메모 | uspto-grants-2003_12 |