HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 3-Cyano-5-fluoro-benzoic acid chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-Cyano-5-fluorobenzoic acid | HCID 2757963 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Cyano-5-fluoro-benzoic acid chloride | HCID 21942593 | — |
Reaction Steps
3-Fluoro-5-cyanobenzoic acid (2.5 g, 15.14 mmol) was treated with a solution of oxalyl chloride (30 mL of 2.5 M in dichloromethane, 75 mmol) and a catalytic amount of N,N-dimethylformamide. The reaction was stirred at ambient temperature for 2.5 hours. The excess oxalyl chloride was removed in vacuo to afford 3-fluoro-5-cyanobenzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06660753B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-31324f00a1f6494ba57a01cb85e76eef |
| Source note | uspto-grants-2003_12 |