HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-(2-Pyridyl)-5-(5-methylpyrid-3-yl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-Methylnicotinic acid | HCID 256208 | — |
| Reactant | 5-Methylnicotinoyl chloride | HCID 14538055 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(2-Pyridyl)-5-(5-methylpyrid-3-yl)-1,2,4-oxadiazole | HCID 9964733 | 47% |
Reaction Steps
In a similar fashion, 5-methylnicotinoyl chloride was prepared from 5-methyinicotinic acid (548 mg, 4 mmoles). Treatment of the acid chloride with pyrid-2-ylamidoxime (822 mg, 6 mmol) and triethylamine (1.2g, 12 mmol) in dichloromethane (6 mL), followed by heating in dimethylformamide (6 mL) at 120° C. for 2.5 hours, afforded 448 mg (47%) of 3-(2-pyridyl)-5-(5-methyl-pyrid-3-yl)-1,2,4-oxadiazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06660753B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-f24a1647d41142cd9269a56d2a4f9879 |
| Source note | uspto-grants-2003_12 |