HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 3-(Pyridin-2-yl)-5-[5-(5-pyrimidyl)-pyrid-3-yl]-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (Pyrimidin-5-yl)boronic acid | HCID 2795193 | — |
| Reactant | 3-(Pyridin-2-yl)-5-(5-bromopyrid-3-yl)-1,2,4-oxadiazole | HCID 11426638 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 3-(Pyridin-2-yl)-5-[5-(5-pyrimidyl)-pyrid-3-yl]-1,2,4-oxadiazole | HCID 9966153 | 7.6% |
Reaction Steps
In a similar fashion, 3-(2-pyridyl)-5-(5-bromo-pyrid-3-yl)-1,2,4-oxadiazole (42 mg, 0.1385 mmole), 5-pyrimidylboronic acid (26.6 mg,0.208 mmole) and Pd(PPh3)4 (23.99 mg, 0.021 mmole) in a solution of 2M sodium carbonate (1.5 mL) and ethylene glycol dimethyl ether (1.5 mL) was heated overnight at 105° C. Standard workup afforded 3.2 mg (8%) of 3-(2-pyridyl)-5-[5-(5-pyrimidyl)-pyrid-3-yl ]-1,2,4-oxadiazole (3.2 mg, 7.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06660753B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-0c28e47234a84fc4bf2a482aeed2dc88 |
| Source note | uspto-grants-2003_12 |