HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 431947Generated: October 31, 2026
3-(Pyridin-2-yl)-5-(5-bromo-2-methoxyphenyl)-1,2,4-oxadiazole → HCID 9945393, compound
https://huagongshe.com/reaction/431947
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(Pyridin-2-yl)-5-(5-bromo-2-methoxyphenyl)-1,2,4-oxadiazole | HCID 10131637 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 9945393 | HCID 9945393 | 25.4% |
Reaction Steps
In a similar fashion, a mixture of 3-(2-pyridyl)-5-(5-bromo-2-methoxyphenyl)-1,2,4-oxadiazole (110 mg, 0.331 mmol), pyridine-2-tributyltin (138.8 mg,0.663 mmole) and Pd(PPh3)4 (38.5 mg, 0.0333 mmole) in tetrahydrofuran (1 mL) was heated in a sealed vial overnight at 100° C. Standard work up afforded 13.9 mg (13%) 3-(2-pyridyl)-5-[2-methoxy-5-(2-pyridyl)phenyl]-1,2,4-oxadiazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06660753B2 |
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| Source dataset | uspto-grants-2003_12 |
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| ORD ID | ord-e37d5310337147cabda2f9a9c26d8a86 |
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| Source note | uspto-grants-2003_12 |
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