HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide → HCID 44514182, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide | HCID 44514746 | — |
| Reactant | 5-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid | HCID 59292911 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 44514182 | HCID 44514182 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Step 14.1 but using 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid (Step 159.1), 5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine (Example 31; purified by silica gel column chromatography), and stirring the reaction mixture for 20 h at rt. Title compound: ESI-MS: 566.1 [M+H]+; TLC: Rf=0.22 (DCM/MeOH, 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536175B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-75c21b229ed54a68b25293f783991a9f |
| Source note | uspto-grants-2013_09 |