HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → Piperazine,1-[4-(4-chlorophenyl)butyl]-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 1-Chloro-4-(4-chlorobutyl)benzene | HCID 20082732 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Piperazine,1-[4-(4-chlorophenyl)butyl]- | HCID 14097058 | 46.3% |
Reaction Steps
A mixture of 26.4 g of 4-(4-chlorophenyl)butyl chloride, 86.1 g of anhydrous piperazine and 250 ml of reagent ethanol was refluxed overnight. Solvent was evaporated from the product and the residue was chromatographed twice on silica with the eluant being CH2Cl2 /CH3OH/ammonium hydroxide (45:5:1). The first chromatography removed the bulk of the excess piperazine, the second provided 15.2 g of 1-[4-(4-chlorophenyl)butyl]piperazine as a colorless oil which solidified on standing (m.p. 139°-145° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04725597 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-81005d9a5e474ae9811ee087317133f2 |
| Source note | uspto-grants-1988_02 |