HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 5-Methylisoxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 2-Aminobenzoxazole | HCID 20707 | — |
| Reactant | Acetonitrile tetrahydrofuran | HCID 22177404 | — |
| Product | 5-Methylisoxazole-4-carboxylic acid | HCID 1425240 | — |
Reaction Steps
Sulfonylation (X═SO2) For 45 μmol of aminobenzoxazole resin in each well of a 96-well microtiter plate, 1 mL RSO2Cl/THF-ACN /NMM/NMI (0.3M, 0.3 mmol RSO2Cl; 20% THF-ACN (by volume); 0.6M, 0.6 mmol NMM; 0.1M, 0.1 mmol NMI) was added to each well. The sulfonyl chlorides (RSO2Cl) used were as follows:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06660858B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-dd31873a1292414294ef4b7a133d933b |
| Source note | uspto-grants-2003_12 |