Maleic Acid → 1-[1-(1-methyl-4-piperidyl)tetrahydro-1H-3-pyrrolyl]-3-(4-phenoxyphenyl)-1H-pyrazolo [3,4-d]pyrimidin-4-amine, trimaleate salt

Participants

Reaction Steps

1-[1-(1-Methyl-4-piperidyl)tetrahydro-1H-3-pyrrolyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (148 mg, 0.315 mmol) was dissolved in hot ethyl acetate (20 mL) and maleic acid (110 mg, 0.946 mmol) in hot ethyl acetate (1 mL) was added. The reaction mixture was stirred at room temperature for 5 hours. The solid was collected by filtration to give 1-[1-(1-methyl-4-piperidyl)tetrahydro-1H-3-pyrrolyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, trimaleate salt (230 mg, 90%). 1H NMR (DMSO-d6) δ 1.81 (m, 2H), 2.27 (m, 2H), 2.78 (s, 3H), 2.97-3.84 (bm, 1H), 5.63 (m, 1H), 6.12 (s, 6H), 7.17 (m, 5H), 7.45 (m, 2H), 7.68 (m, 2H), 8.29 (s, 1H). LCMS (Micromass-Column: Pecosphere, C18, 3 um, 33×4.6 mm. Eluents: 0% B/A to 100% B/A in 4.5 min. (B: acetonitrile, A: 50 mM ammonia acetate buffer, PH 4.5), 3.5 mL/min.): MH+ =470.4, Rt=2.01.

Provenance & Evidence