反应详情

A solution of 4-bromoaniline (5.48 g, 0.0318 mol) and phenylsuccinic anhydride (5.89 g, 0.0334 mol) in anhydrous benzene (80 mL) was heated at reflux for one and a half hours. The mixture was cooled to ambient temperature and concentrated under reduced pressure. To the residue, acetyl chloride (60 mL) was added and the solution was heated at reflux for one and a half hours. The reaction mixture was cooled to ambient temperature and the precipitate collected by filtration, washed with diethyl ether and dried to yield 1-(4-bromophenyl)-3-phenyl-2,5-pyrrolidinedione (8.7 g, 0.0264 mol) as an off-white solid.

1. temperatureat reflux for one and a half hours
2. concentrationconcentrated under reduced pressure
3. additionTo the residue, acetyl chloride (60 mL) was added
4. temperaturethe solution was heated
5. temperatureat reflux for one and a half hours
6. temperatureThe reaction mixture was cooled to ambient temperature
7. filtrationthe precipitate collected by filtration
8. washwashed with diethyl ether
9. customdried