HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 432567Generated: October 31, 2026
Water → 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate
https://huagongshe.com/reaction/432567
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-Bromo-2,2-dimethylpropyl acetate | HCID 13357715 | — |
| Reactant | HCID 178420772 | HCID 178420772 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate | HCID 54518815 | — |
Reaction Steps
To a solution of 4-pyridin-3-yl-imidazole (50 mg) in DMSO (methyl sulfoxide) (1.7 mL) was added powered KOH (57 mg) and 3-bromo-2,2-dimethylpropyl acetate and the resulting suspension was heated at 70° C. for 48 hours. Water was added followed by CHCl3, the aqueous layer was extracted with CHCl3, the combined organic layers were washed with brine, dired over Na2SO4 and evaporated in vacuo. The redisue was purified by preparative TLC (10% MeOH-90% CH2Cl2) the title compound as slightly yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06664238B1 |
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| Source dataset | uspto-grants-2003_12 |
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| ORD ID | ord-2040a0ba66db4bc4aaea4c1bbbd3f2db |
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| Source note | uspto-grants-2003_12 |
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