Water → 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Potassium Hydroxide	HCID 14797	—
Reactant	3-Bromo-2,2-dimethylpropyl acetate	HCID 13357715	—
Reactant	HCID 178420772	HCID 178420772	—
Solvent	Dimethyl Sulfoxide	HCID 679	—
Solvent	Chloroform	HCID 6212	—
Product	2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate	HCID 54518815	—

Reaction Conditions

Temperature	70 °C

Reaction Steps

To a solution of 4-pyridin-3-yl-imidazole (50 mg) in DMSO (1.7 mL) was added powered KOH (57 mg) and 3-bromo-2,2-dimethylpropyl acetate and the resulting suspension was heated at 70° C. for 48 hours. Water was added followed by CHCl3, the aqueous layer was extracted with CHCl3, the combined organic layers were washed with brine, dired over Na2SO4 and evaporated in vacuo. The residue was purified by preparative TLC (10% MeOH-90% CH2Cl2) the title compound as slightly yellow oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06664238B1
Source dataset	uspto-grants-2003_12
ORD ID	ord-acb142e284154a0bbf859dcb7908e8a6
Source note	uspto-grants-2003_12