Diisopropylethylamine → HCID 15896093, compound

Participants

Reaction Steps

To a solution of the carboxylic acid from Example 6 (0.109, 0.25 mmol) in dichloromethane (25 ml) was added DIEA (0.221 ml, 1.26 mmol) and PyBroP (0.129 g, 0.278 mmol). The mixture was stirred at room temperature for 10 min and then methylamine hydrochloride (0.085 g, 1.26 mmol) was added. Stirring was continued for a further 3 h. The mixture was then washed with 1M KHSO4 (3 times), saturated sodium bicarbonate solution (3 times) and brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash chromatography on silica (eluant dichloromethane:methanol 96:4) to give a white solid; yield 0.018 g (17%).

Provenance & Evidence